Vitamin K2

Vitamin K2 help regulate blood clotting, bone metabolism, and blood calcium levels. It protects against cancer, may suppress genetic processes that lead to tumor growth, helps normalize blood glucose, and reduces symptoms of anxiety and depression.

Dietary Intake of Vitamin K and Risk of Prostate Cancer in the Heidelberg Cohort of the European Prospective Investigation Into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. https://pubmed.ncbi.nlm.nih.gov/18400723-dietary-intake-of-vitamin-k-and-risk-of-prostate-cancer-in-the-heidelberg-cohort-of-the-european-prospective-investigation-into-cancer-and-nutrition-epic-heidelberg/

Does Vitamin K2 Play a Role in the Prevention and Treatment of Osteoporosis for Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials. Osteoporos Int. https://pubmed.ncbi.nlm.nih.gov/25516361-does-vitamin-k2-play-a-role-in-the-prevention-and-treatment-of-osteoporosis-for-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials/

Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: A Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model. Int J Biol Sci. https://pubmed.ncbi.nlm.nih.gov/27313492-vitamin-k2-ameliorates-damage-of-blood-vessels-by-glucocorticoid-a-potential-mechanism-for-its-protective-effects-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-a-rat-model/

Vitamin K and the Prevention of Fractures.JAMA Internal Medicine https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/410550

Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver.JAMA https://jamanetwork.com/journals/jama/fullarticle/199121

The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment.Cancer https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.21667

Vitamin K2 (Menatetrenone) for Bone Loss in Patients With Cirrhosis of The Liver.The American Journal of Gastroenterology https://journals.lww.com/ajg/Abstract/2002/04000/Vitamin_K2__Menatetrenone__for_Bone_Loss_in.36.aspx

Does Vitamin K2 Play a Role in the Prevention and Treatment of Osteoporosis for Postmenopausal Women: A Meta-Analysis of Randomized Controlled Trials.Osteoporos Int https://www.ncbi.nlm.nih.gov/pubmed/25516361

Vitamin K2 Supplementation in Haemodialysis Patients: A Randomized Dose-Finding Study.Nephrol Dial Transplant https://pubmed.ncbi.nlm.nih.gov/24285428-vitamin-k2-supplementation-in-haemodialysis-patients-a-randomized-dose-finding-study/?from_term=vitamin+k2&from_page=7&from_pos=3

Combined Treatment With Vitamin K2 and PTH Enhanced Bone Formation in Ovariectomized Rats and Increased Differentiation of Osteoblast in Vitro.Chem Biol Interact https://pubmed.ncbi.nlm.nih.gov/30639440-combined-treatment-with-vitamin-k2-and-pth-enhanced-bone-formation-in-ovariectomized-rats-and-increased-differentiation-of-osteoblast-in-vitro/?from_term=vitamin+k2&from_page=4&from_pos=1

Effect of Vitamin K2 on Progression of Atherosclerosis and Vascular Calcification in Nondialyzed Patients With Chronic Kidney Disease Stages 3-5.Pol Arch Med Wewn https://www.ncbi.nlm.nih.gov/pubmed/26176325

Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise.Altern Ther Health Med https://pubmed.ncbi.nlm.nih.gov/28646812-oral-consumption-of-vitamin-k2-for-8-weeks-associated-with-increased-maximal-cardiac-output-during-exercise/?from_term=vitamin+k2&from_page=2&from_pos=3

The Effects of Vitamin K1 and Vitamin K2 on the Proliferation, Cytokine Production and Regulatory T-cell Frequency in Peripheral Blood Mononuclear Cells of Paediatric Atopic Dermatitis Patients.Exp Dermatol https://pubmed.ncbi.nlm.nih.gov/29697859-the-effects-of-vitamin-k1-and-vitamin-k2-on-the-proliferation-cytokine-production-and-regulatory-t-cell-frequency-in-peripheral-blood-mononuclear-cells-of-paediatric-atopic-dermatitis-patients/?from_term=vitamin+k2&from_page=5&from_pos=5

Vitamin K1 and Vitamin K2 Immunopharmacological Effects on the Peripheral Lymphocytes of Healthy Subjects and Dialysis Patients, as Estimated by the Lymphocyte Immunosuppressant Sensitivity Test.J Clin Pharm Ther https://pubmed.ncbi.nlm.nih.gov/30014604-vitamin-k1-and-vitamin-k2-immunopharmacological-effects-on-the-peripheral-lymphocytes-of-healthy-subjects-and-dialysis-patients-as-estimated-by-the-lymphocyte-immunosuppressant-sensitivity-test/?from_term=vitamin+k2&from_page=2&from_pos=9

Vitamin K2 Ameliorates Damage of Blood Vessels by Glucocorticoid: A Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model.Int J Biol Sci https://pubmed.ncbi.nlm.nih.gov/27313492-vitamin-k2-ameliorates-damage-of-blood-vessels-by-glucocorticoid-a-potential-mechanism-for-its-protective-effects-in-glucocorticoid-induced-osteonecrosis-of-the-femoral-head-in-a-rat-model/?from_term=vitamin+k2&from_page=6&from_pos=3

Vitamin K2 Improves Anxiety and Depression but Not Cognition in Rats With Metabolic Syndrome: A Role of Blood Glucose?Folia Med (Plovdiv) https://pubmed.ncbi.nlm.nih.gov/28068285-vitamin-k2-improves-anxiety-and-depression-but-not-cognition-in-rats-with-metabolic-syndrome-a-role-of-blood-glucose/?from_term=vitamin+k2&from_page=4&from_pos=10

Vitamin K 2 Alleviates Type 2 Diabetes in Rats by Induction of Osteocalcin Gene Expressi.Nutrition https://pubmed.ncbi.nlm.nih.gov/29429532-vitamin-k-2-alleviates-type-2-diabetes-in-rats-by-induction-of-osteocalcin-gene-expression/?from_term=vitamin+k2&from_page=8&from_pos=7

Effects of Vitamin K2 (Menatetrenone) on Atherosclerosis and Blood Coagulation in Hypercholesterolemic Rabbits.Jpn J Pharmacol https://pubmed.ncbi.nlm.nih.gov/9414028-effects-of-vitamin-k2-menatetrenone-on-atherosclerosis-and-blood-coagulation-in-hypercholesterolemic-rabbits/?from_term=vitamin+k2&from_page=8&from_pos=9

Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.PLoS One https://pubmed.ncbi.nlm.nih.gov/27570977-vitamin-k2-induces-mitochondria-related-apoptosis-in-human-bladder-cancer-cells-via-ros-and-jnkp38-mapk-signal-pathways/?from_term=vitamin+k2&from_page=3&from_pos=1

Vitamin K2 Prevents Lymphoma in Drosophila.Sci Rep https://pubmed.ncbi.nlm.nih.gov/29213118-vitamin-k2-prevents-lymphoma-in-drosophila/?from_term=vitamin+k2&from_page=2&from_pos=6

Vitamin K2 Promotes Mesenchymal Stem Cell Differentiation by Inhibiting miR‑133a Expression.Mol Med Rep https://pubmed.ncbi.nlm.nih.gov/28447758-vitamin-k2-promotes-mesenchymal-stem-cell-differentiation-by-inhibiting-mir133a-expression/?from_term=vitamin+k2&from_page=2&from_pos=4

Vitamin K2-enhanced Liver Regeneration Is Associated With Oval Cell Expansion and Up-Regulation of matrilin-2 Expression in 2-AAF/PH Rat Model.Curr Mol Med https://pubmed.ncbi.nlm.nih.gov/24236453-vitamin-k2-enhanced-liver-regeneration-is-associated-with-oval-cell-expansion-and-up-regulation-of-matrilin-2-expression-in-2-aafph-rat-model/?from_term=vitamin+k2&from_page=6&from_pos=9

Vitamin K for the primary prevention of cardiovascular disease.Cochrane Database of Systematic Reviews https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011148.pub2/full