Resveratrol
Resveratrol is polyphenol in red wine. Many studies have demonstrated meaningful cardiovascular benefits, improved outcomes for those with Alzheimer’s disease, anticancer properties, antimicrobial effects, skin care benefits and sirtuin activation, specifically SIRT1 which is employed in employed recombinational repair of DNA breaks.
SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM. Cells. https://www.mdpi.com/2073-4409/7/12/235
Resveratrol preserves mitochondrial function in a human post-mitotic cell model. J Nutr Biochem. https://www.ncbi.nlm.nih.gov/pubmed/30216747
Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism. J Nutr Biochem. https://www.ncbi.nlm.nih.gov/pubmed/29268122
Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients. Nutrients. https://www.ncbi.nlm.nih.gov/pubmed/25329968
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem. https://www.ncbi.nlm.nih.gov/pubmed/20080969
Resveratrol inhibits ovarian tumor growth in an in vivo mouse model.Cancer https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.29793
The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials.Obesity Reviews https://pubmed.ncbi.nlm.nih.gov/27456934/
SIRT-3 Modulation by Resveratrol Improves Mitochondrial Oxidative Phosphorylation in Diabetic Heart through Deacetylation of TFAM.Cells https://www.mdpi.com/2073-4409/7/12/235
Resveratrol preserves mitochondrial function in a human post-mitotic cell model.J Nutr Biochem https://www.ncbi.nlm.nih.gov/pubmed/30216747
Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism.J Nutr Biochem https://www.ncbi.nlm.nih.gov/pubmed/29268122
Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients.Nutrients https://www.ncbi.nlm.nih.gov/pubmed/25329968
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.J Biol Chem https://www.ncbi.nlm.nih.gov/pubmed/20080969
Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.Scientific Reports https://www.nature.com/articles/srep21772
Effects of Resveratrol in Goto-Kakizaki Rat, a Model of Type 2 Diabetes.Nutrients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836277/
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells.Cancer Letters https://www.sciencedirect.com/science/article/abs/pii/S0304383515007223
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.Journal of cellular physiology https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.25443
Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death.Cell Death & Disease https://www.nature.com/articles/cddis20166#Sec9
A meta-analysis of resveratrol protects against myocardial ischemia/reperfusion injury: evidence from small animal studies and insight into molecular mechanisms.Oxidative Medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512035/pdf/OMCL2019-5793867.pdf
Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.Critical Reviews in Food Science and Nutrition
https://www.tandfonline.com/doi/abs/10.1080/10408398.2017.1349076?journalCode=bfsn20″,”Journal Link “
Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis.Ageing Research Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235673/pdf/nihms-987635.pdf
Resveratrol levels and all-cause mortality in older community-dwelling adults.JAMA Internal Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346286/pdf/nihms665943.pdf
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.American Journal of Clinical Nutrition https://academic.oup.com/ajcn/article/91/6/1590/4597194
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease.Journal of Neuroinflammation https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0779-0
Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.Aging https://pubmed.ncbi.nlm.nih.gov/28611316-effects-of-resveratrol-curcumin-berberine-and-other-nutraceuticals-on-aging-cancer-development-cancer-stem-cells-and-micrornas/
Effect of resveratrol on cognitive and memory performance and mood: a meta-analysis of 225 patients.Pharmacological Research https://pubmed.ncbi.nlm.nih.gov/28844841-effect-of-resveratrol-on-cognitive-and-memory-performance-and-mood-a-meta-analysis-of-225-patients/
Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells.Drug Des Devel Ther https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30863014/
Combined metformin and resveratrol confers protection against UVC-induced DNA damage in A549 lung cancer cells via modulation of cell cycle checkpoints and DNA repair.Oncol Rep https://www.ncbi.nlm.nih.gov/pubmed/27109601
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.J Agric Food Chem https://www.ncbi.nlm.nih.gov/pubmed/19928762
Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.American journal of physiology – heart and circulatory physiology https://www.physiology.org/doi/full/10.1152/ajpheart.00455.2016
The effect of resveratrol on longevity across species: a meta-analysis.Biology Letters https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440975/
Effect of resveratrol and pterostilbene on aging and longevity.Biofactors https://pubmed.ncbi.nlm.nih.gov/29210129-effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity/
Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.Clinical Nutrition https://pubmed.ncbi.nlm.nih.gov/24731650-effect-of-resveratrol-on-blood-pressure-a-meta-analysis-of-randomized-controlled-trials/
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis.Cancer Research https://cancerres.aacrjournals.org/content/70/22/9003
One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease.The American Journal of Cardiology https://www.ajconline.org/article/S0002-9149(12)01046-6/fulltext
Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial.Nutrition https://www.sciencedirect.com/science/article/abs/pii/S0899900718306142
A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones.Journal of Translational Medicine https://www.sciencedirect.com/science/article/abs/pii/S0899900718306142
Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta‐analysis.Annals of the New York Academy of Sciences https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/nyas.14226
Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors – results from a systematic review and meta-analysis of randomized controlled trials.International Journal of Cardiology https://pubmed.ncbi.nlm.nih.gov/25885871-lack-of-efficacy-of-resveratrol-on-c-reactive-protein-and-selected-cardiovascular-risk-factors-results-from-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials/
Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer.Nutrition and Cancer https://www.tandfonline.com/doi/full/10.1080/01635581.2012.654926?scroll=top&needAccess=true
The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food and Function https://pubs.rsc.org/en/content/articlelanding/2018/FO/C8FO01259H#!divAbstract
Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells.Scientific Reports https://www.nature.com/articles/s41598-019-50416-5
Effect of resveratrol on lipid profile: An updated systematic review and meta-analysis on randomized clinical trials.Pharamcological Research https://www.sciencedirect.com/science/article/abs/pii/S1043661817311593?via%3Dihub
Effect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta‐Analysis.Obesity https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22348
A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma.British Journal of Haematology https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.12154
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