Nicotinamide Mononucleotide (NMN)

“Longevity genes” called sirtuins help you live a longer, healthier life by detecting errors and fixing them. Sirtuins need NAD (nicotinamide adenine dinucleotide) to function. We lose NAD in the body as we age. Nicotinamide mononucleotide (“NMN”) enhances NAD production, helping to keep it at levels usually found in youth.

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism. https://www.sciencedirect.com/science/article/pii/S1550413116304958

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology. https://www.sciencedirect.com/science/article/pii/S221323171930240X

The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell. https://www.sciencedirect.com/science/article/pii/S0092867413007551

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journal. https://www.embopress.org/doi/full/10.15252/embj.201386907

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell metabolism. https://www.sciencedirect.com/science/article/pii/S1550413116304958

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413116304958

NAD Replenishment With Nicotinamide Mononucleotide Protects Blood-Brain Barrier Integrity and Attenuates Delayed Tissue Plasminogen Activator-Induced Haemorrhagic Transformation After Cerebral Ischaemia. Br J Pharmacol http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5647191/

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.Diabetologia https://link.springer.com/article/10.1007/s00125-011-2288-0

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice.Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413116304958

NAD+ Intermediates: The biology and therapeutic potential of NMN and NR.Cell metabolism https://pubmed.ncbi.nlm.nih.gov/29249689-nad-intermediates-the-biology-and-therapeutic-potential-of-nmn-and-nr

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model. BMC Neurology https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0272-x

Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men. Endocr J https://www.ncbi.nlm.nih.gov/pubmed/31685720

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front Pharmacol https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27594836/

Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Hum Genomics https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31823815/

Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats. J Cardiovasc Pharmacol Ther https://www.ncbi.nlm.nih.gov/pubmed/31645107

Nicotinamide Mononucleotide (NMN) Supplementation Ameliorates the Impact of Maternal Obesity in Mice: Comparison With Exercise. Scientific Reports https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678092/

Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects. GeroScience https://link.springer.com/article/10.1007/s11357-019-00095-x

Nicotinamide mononucleotide alleviates Aluminum induced bone loss by inhibiting the TXNIP-NLRP3 inflammasome. Toxicology and applied pharmacology https://www.sciencedirect.com/science/article/pii/S0041008X18304642

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice.Journal of Affective Disorders https://www.sciencedirect.com/science/article/abs/pii/S0165032719322438

Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus. Neuroscience https://www.sciencedirect.com/science/article/abs/pii/S0306452219306827

Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway. Scientific Reports https://www.nature.com/articles/s41598-017-00851-z

Nicotinamide Mononucleotide Inhibits JNK Activation to Reverse Alzheimer Disease. Neurosci Lett https://linkinghub.elsevier.com/retrieve/pii/S030439401730246X

Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia. Neurobiology of Disease https://www.sciencedirect.com/science/article/pii/S0969996116301760

Nicotinamide Mononucleotide Preserves Mitochondrial Function and Increases Survival in Hemorrhagic Shock. JCI Insight http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6171817/

Nicotinamide Mononucleotide Protects Against β-Amyloid Oligomer-Induced Cognitive Impairment and Neuronal Death. Brain Res https://doi.org/10.1016/j.brainres.2016.04.060

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLOS ONE https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905194/

Protective effects of nicotinamide mononucleotide against oxidative stress-induced PC12 cell death via mitochondrial enhancement.PharmaNutrition https://www.sciencedirect.com/science/article/pii/S2213434419301872

Short-term Administration of Nicotinamide Mononucleotide Preserves Cardiac Mitochondrial Homeostasis and Prevents Heart Failure. J Mol Cell Cardiol http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6257991/

NAD+ Deficits in Age-related Diseases and Cancer. Trends in Cancer https://pubmed.ncbi.nlm.nih.gov/28780936-nad-deficits-in-age-related-diseases-and-cancer/

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence Cell metabolism https://pubmed.ncbi.nlm.nih.gov/29514064-therapeutic-potential-of-nad-boosting-molecules-the-in-vivo-evidence/

It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging and Mechanisms of Diseasehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514996/pdf/npjamd201617.pdf

Nicotinamide Mononucleotide Supplementation Reverses Vascular Dysfunction and Oxidative Stress With Aging in Mice. Aging Cell https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854911/

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice . Cell metabolism https://www.sciencedirect.com/science/article/pii/S1550413111003469

The NAD+/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signalling. Cell https://www.sciencedirect.com/science/article/pii/S0092867413007551

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO Journalhttps://www.embopress.org/doi/full/10.15252/embj.201386907

NAD+ Therapy in Age-related Degenerative Disorders: A benefit/risk analysis. Experimental Gerontology https://pubmed.ncbi.nlm.nih.gov/31917996-nad-therapy-in-age-related-degenerative-disorders-a-benefitrisk-analysis/

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH☆. Journal of Molecular and Cellular Cardiology https://www.sciencedirect.com/science/article/pii/S0022282818303614

The first human clinical study for NMN has started in Japan. npj Aging and Mechanisms of Disease. https://www.nature.com/articles/npjamd201621.pdf