Berberine

Berberine appears to work by slowing a metabolic pathway that causes inflammation and increasing activity of the AMPK enzyme and its downstream targets, including mTOR and SIRT1 (much like the prescription drug metformin).  It supports healthy blood sugar levels, promotes cardiovascular health and weight loss.

Berberine lowers blood glucose in type 2 diabetes melitus patients through increasing insulin receptor expression.  Metabolism Clinical and Experimental.  https://pubmed.ncbi.nlm.nih.gov/19800084-berberine-lowers-blood-glucose-in-type-2-diabetes-mellitus-patients-through-increasing-insulin-receptor-expression/     

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.  Nature.  https://pubmed.ncbi.nlm.nih.gov/15531889-berberine-is-a-novel-cholesterol-lowering-drug-working-through-a-unique-mechanism-distinct-from-statins/            

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled studyBerberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study.  The Lancet.   https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30409-1/fulltext

Efficacy and safety of berberine for congestive heart failure secondarto ischemic or idiopathic dilated cardiomyopathy.  American Journal of Cardiology.  https://pubmed.ncbi.nlm.nih.gov/12860219-efficacy-and-safety-of-berberine-for-congestive-heart-failure-secondary-to-ischemic-or-idiopathic-dilated-cardiomyopathy/

Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism Clinical and Experimental https://pubmed.ncbi.nlm.nih.gov/18640378-combination-of-simvastatin-with-berberine-improves-the-lipid-lowering-efficacy/

Berberine lowers blood glucose in type 2 diabetes melitus patients through increasing insulin receptor expression. Metabolism Clinical and Experimental https://pubmed.ncbi.nlm.nih.gov/19800084-berberine-lowers-blood-glucose-in-type-2-diabetes-mellitus-patients-through-increasing-insulin-receptor-expression/

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nature Medicine https://pubmed.ncbi.nlm.nih.gov/15531889-berberine-is-a-novel-cholesterol-lowering-drug-working-through-a-unique-mechanism-distinct-from-statins/

Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. The Lancet Gastroenterology and Hepatology

https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30409-1/fulltext

berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistance states. Diabetes https://diabetes.diabetesjournals.org/content/diabetes/55/8/2256.full.pdf

Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Journal of Clinical Endocrinology and Metabolism  https://pubmed.ncbi.nlm.nih.gov/18397984-treatment-of-type-2-diabetes-and-dyslipidemia-with-the-natural-plant-alkaloid-berberine/

Combined nutraceutical approach to postmenopausal syndrome and vascular remodeling biomarkers. The Journal of Alternative and Complementary Medicine https://pubmed.ncbi.nlm.nih.gov/23308361-combined-nutraceutical-approach-to-postmenopausal-syndrome-and-vascular-remodeling-biomarkers/

Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. Arzneimittel Forschung – Drug Research https://pubmed.ncbi.nlm.nih.gov/17341006-eulipidemic-effects-of-berberine-administered-alone-or-in-combination-with-other-natural-cholesterol-lowering-agents-a-single-blind-clinical-investigation/

Efficacy and safety of berberine for congestive heart failure secondarto ischemic or idiopathic dilated cardiomyopathy. American Journal of Cardiology https://pubmed.ncbi.nlm.nih.gov/12860219-efficacy-and-safety-of-berberine-for-congestive-heart-failure-secondary-to-ischemic-or-idiopathic-dilated-cardiomyopathy/

Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. Gynecological Endocrinology https://pubmed.ncbi.nlm.nih.gov/22313171-activity-of-isoflavones-and-berberine-on-vasomotor-symptoms-and-lipid-profile-in-menopausal-women/

Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arteriosclerosis, Thrombosis, and Vascular Biology  https://pubmed.ncbi.nlm.nih.gov/16100034-extracellular-signal-regulated-kinase-dependent-stabilization-of-hepatic-low-density-lipoprotein-receptor-mrna-by-herbal-medicine-berberine/

Improvement of superoxide dismutase and catalase in streptozotocin-nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide. Pharmaceutical Biology https://pubmed.ncbi.nlm.nih.gov/24188560-improvement-of-superoxide-dismutase-and-catalase-in-streptozotocin-nicotinamide-induced-type-2-diabetes-in-mice-by-berberine-and-glibenclamide/

Effects of a new nutraceutical formulation (berberine, red yeast rice and chitosan) on non-HDL cholesterol levels in individuals with dyslipidemia: results from a randomized, double blind, placebo-controlled study. International Journal of Molecular Sciences https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535988/pdf/ijms-18-01498.pdf

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer’s disease transgenic mouse model. Neurobiology of Aging https://www.sciencedirect.com/science/article/abs/pii/S0197458012001613

Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice. Journal of Cellular and Molecular Medicine https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.12645

Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clinical and Experimental Pharmacology and Physiology https://pubmed.ncbi.nlm.nih.gov/22220931-berberine-ameliorates-inflammation-in-patients-with-acute-coronary-syndrome-following-percutaneous-coronary-intervention/

Berberine improves glucose metabolism through induction of glycolysis. American Journal of Physiology, Endocrinology and Metabolism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464622/pdf/nihms50546.pdf

Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta  https://pubmed.ncbi.nlm.nih.gov/20298851-effect-of-traditional-chinese-medicine-berberine-on-type-2-diabetes-based-on-comprehensive-metabonomics/

The preconditioning of berberine suppresses hydrogen peroxide-induced premature senescence via regulation of Sirtuin 1. Oxidative medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511663/

Berberine alleviates amyloid beta-induced mitochondrial dysfunction and synaptic loss.Oxidative medicine and Cellular Longevity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525905/pdf/OMCL2019-7593608.pdf

A Phase I Trial of Berberine in Chinese with Ulcerative Colitis.Cancer Prevention Research  https://cancerpreventionresearch.aacrjournals.org/content/early/2019/10/11/1940-6207.CAPR-19-0258

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition.Cell Death and Disease  https://www.nature.com/articles/cddis2017471

Anti-hypertensive and renoprotective effects of berberine in spontaneously hypertensive rats.Clinical and Experimental Hypertension https://www.tandfonline.com/doi/abs/10.3109/10641963.2014.972560

Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice.International Immunopharmacology  https://www.sciencedirect.com/science/article/pii/S1567576916302661

Berberine Attenuated Aging-Accelerating Effect of High Temperature in Drosophila Model.Am J Plant Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498585/

Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy.Molecular and Cellular Endocrinology https://www.sciencedirect.com/science/article/abs/pii/S0303720717300138

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats.The journal of nutrition, health & aging https://link.springer.com/article/10.1007/s12603-018-1015-7

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans.International Journal of Cardiology https://www.sciencedirect.com/science/article/abs/pii/S0167527312002951

Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson’s disease.International Journal of Molecular Medicine https://www.spandidos-publications.com/ijmm/33/4/870?text=fulltext

Berberine Prolongs Life Span and Stimulates Locomotor Activity of Drosophila melanogaster.Am J Plant Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498586/

Berberine suppresses neuroinflammatory responses through AMP‐activated protein kinase activation in BV‐2 microglia.European Journal of Pharmacology https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.22580

Effects of berberine on β-secretase activity in a rabbit model of Alzheimer’s disease.Arch Med Sci https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598150/

Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats.Chinese Medicine https://cmjournal.biomedcentral.com/articles/10.1186/1749-8546-5-33

Neuroprotective effect of berberine is mediated by MAPK signaling pathway in experimental diabetic neuropathy in rats.European Journal of Pharmacology https://www.sciencedirect.com/science/article/pii/S0014299916300188

Neuroprotective effect of berberine against environmental heavy metals-induced neurotoxicity and Alzheimer’s-like disease in rats.Food and Chemical Toxicology https://www.sciencedirect.com/science/article/pii/S0278691517306932

Antitumor effect of novel berberine derivatives in breast cancer cells.BioFactors https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/biof.1131

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.Behavioural Brain Research https://doi.org/10.1016/j.bbr.2011.01.022

Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice.Rejuvenation Research https://www.liebertpub.com/doi/full/10.1089/rej.2017.1972

Berberine modulates insulin signaling transduction in insulin-resistant cells.Molecular and Cellular Endocrinology https://europepmc.org/article/med/20036710

Effect of berberine on regression of pressure-overload induced cardiac hypertrophy in rats.The American Journal of Chinese Medicine https://pubmed.ncbi.nlm.nih.gov/12568286-effect-of-berberine-on-regression-of-pressure-overload-induced-cardiac-hypertrophy-in-rats/

Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis.BMC Cancer https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5791-1

Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies.BMC Complementary and Alternative Medicine volume https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2510-z

Berberine Reverses Epithelial-to-Mesenchymal Transition and Inhibits Metastasis and Tumor-Induced Angiogenesis in Human Cervical Cancer Cells.Molecular Pharmacology  http://molpharm.aspetjournals.org/content/86/6/609

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine.The Journal of Clinical Endocrinology & Metabolism https://academic.oup.com/jcem/article/93/7/2559/2598635

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.Plos One  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134172

 

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