Fisetin

Fisetin is a senotherapeutic that extends health and lifespan.EbIoMedicine https://www.sciencedirect.com/science/article/pii/S2352396418303736

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice.Aging Cell https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12185

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies.Trends in Food Science & Technology https://www.sciencedirect.com/science/article/abs/pii/S0924224417302091

GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae Through β-Catenin Activation.Int J Mol Sci https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31906440/

Exploring the molecular targets of dietary flavonoid fisetin in cancer.Seminars in Cancer Biology https://www.sciencedirect.com/science/article/pii/S1044579X16300128

Fisetin is a senotherapeutic that extends health and lifespan.EbIoMedicine https://www.sciencedirect.com/science/article/pii/S2352396418303736

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer’s disease transgenic mice.Aging Cell https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12185

GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae Through β-Catenin Activation.Int J Mol Sci https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31906440/

Exploring the molecular targets of dietary flavonoid fisetin in cancer.Seminars in Cancer Biology https://www.sciencedirect.com/science/article/pii/S1044579X16300128

Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.Food and Function https://pubs.rsc.org/en/content/articlelanding/2018/FO/C7FO01898C#!divAbstract

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse.The Journals of Gerontology https://academic.oup.com/biomedgerontology/article/73/3/299/3860587

Fisetin and 5‐fluorouracil: Effective combination for PIK3CA‐mutant colorectal cancer.The International Journal of Cancer https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32367

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463.Aging https://www.aging-us.com/article/101202/text

Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice.Molecular Neurobiology https://link.springer.com/article/10.1007/s12035-016-9795-4

Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling.The Journal of Nutritional Biochemistry https://www.sciencedirect.com/science/article/abs/pii/S0955286319301408

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity.Scientific reports https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32076073/

Fisetin protects against hepatosteatosis in mice by inhibiting miR‐378.Molecular Nutrition & Food Research https://doi.org/10.1002/mnfr.201300071

Fisetin Antagonizes Cell Fusion, Cytoskeletal Organization and Bone Resorption in RANKL-differentiated Murine Macrophages.J Nutr Biochem https://pubmed.ncbi.nlm.nih.gov/24524902-fisetin-antagonizes-cell-fusion-cytoskeletal-organization-and-bone-resorption-in-rankl-differentiated-murine-macrophages/?from_term=fisetin&from_filter=years.2013-2013&from_size=20&from_pos=6

Fisetin Regulates Obesity by Targeting mTORC1 Signaling.J Nutr Biochem https://doi.org/10.1016/j.jnutbio.2013.01.003

Fisetin Exerts Antihyperalgesic Effect in a Mouse Model of Neuropathic Pain: Engagement of Spinal Serotonergic System.Scientific reports https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25761874/

Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Tria.Clinical and Applied Thrombosis/Hemostasis https://journals.sagepub.com/doi/full/10.1177/1076029619871359

Fisetin, a potential caloric restriction mimetic, modulates ionic homeostasis in senescence induced and naturally aged rats.Archives of Physiology and Biochemistry https://www.tandfonline.com/doi/abs/10.1080/13813455.2019.1662452

Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.European Journal of Pharmacology https://www.sciencedirect.com/science/article/abs/pii/S0014299919307009

Flavonoid Fisetin Alleviates Kidney Inflammation and Apoptosis via Inhibiting Src-mediated NF-κB p65 and MAPK Signaling Pathways in Septic AKI Mice.Biomedicine & pharmacotherapy https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(19)35394-6

Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson’s Disease.J Diet Suppl https://www.tandfonline.com/doi/full/10.1080/19390211.2019.1710646

Fisetin Regulates Gut Microbiota to Decrease CCR9 +/CXCR3 +/CD4 + T-lymphocyte Count and IL-12 Secretion to Alleviate Premature Ovarian Failure in Mice.Am J Transl Res https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32051749/

Cytoprotective Effects of Fisetin Against Hypoxia-Induced Cell Death in PC12 Cells.Food Funct https://doi.org/10.1039/c4fo00948g

Fisetin Inhibits TNF-α-induced Inflammatory Action and Hydrogen Peroxide-Induced Oxidative Damage in Human Keratinocyte HaCaT Cells Through PI3K/AKT/Nrf-2-mediated Heme oxygenase-1 Expression.Int Immunopharmacol https://doi.org/10.1016/j.intimp.2015.11.014

Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways.Cellular and Molecular Neurobiology https://doi.org/10.1007/s10571-015-0272-9

Fisetin Inhibits UVB-induced Cutaneous Inflammation and Activation of PI3K/AKT/NFκB Signaling Pathways in SKH-1 Hairless Mic.Photochem Photobiol https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25169110/

Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats.Endocrine https://link.springer.com/article/10.1007%2Fs12020-012-9866-x

Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system.In Vitro Cellular & Developmental Biology – Animal https://link.springer.com/article/10.1007%2Fs11626-013-9681-6

Fisetin Ameliorates Oxidative Stress, Inflammation and Apoptosis in Diabetic Cardiomyopathy.Life Sci https://pubmed.ncbi.nlm.nih.gov/30742869-fisetin-ameliorates-oxidative-stress-inflammation-and-apoptosis-in-diabetic-cardiomyopathy/?from_term=fisetin&from_filter=years.2019-2019&from_pos=4

Fisetin Alleviates Atrial Inflammation, Remodeling, and Vulnerability to Atrial Fibrillation After Myocardial Infarction.Int Heart J https://www.jstage.jst.go.jp/article/ihj/60/6/60_19-131/_article

The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs.The Journal of Food Biochemistry https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12962

Attenuation of reserpine‑induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol.Experimental and Therapeutic Medicine https://www.spandidos-publications.com/10.3892/etm.2019.8328

Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson’s Disease.Journal of Dietary Supplements https://www.tandfonline.com/doi/abs/10.1080/19390211.2019.1710646?journalCode=ijds20

Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation.Phytomedicine https://www.sciencedirect.com/science/article/abs/pii/S0944711318304707